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nphs2

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Official Full Name
nephrosis 2, idiopathic, steroid-resistant (podocin)
Background
Podocin (NPHS2 protein) is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. It is a hairpin like integral membrane protein with intracellular N and C termini. Podocin is located at the insertion site of the slit membrane, and is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Synonyms
NPHS2; podocin; PDCN; SRN1; nephrosis 2, idiopathic, steroid-resistant (podocin); nphs2l; si:dkey-171o17.6

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