Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
NOS2; nitric oxide synthase 2, inducible; HEP-NOS; NOS; nitric oxide synthase 2A (inducible, hepatocytes); Hepatocyte NOS; Inducible NO synthase; Peptidyl-cysteine S-nitrosylase NOS2; NOS type II; EC 220.127.116.11; INOS; nitric oxide synthase, inducible; nitric oxide synthase, macrophage; NOS, type II; inducible NOS; OTTHUMP00000163279; NOS2A; nitric oxide synthase 2A (inducible, hepatocytes) , NOS2A; HEP NOS; macrophage NOS; inducible nitric oxide synthase; nitric oxide synthase 2A (in