The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from;L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including;neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric;oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke;and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This;protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that;differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known.Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been;found for this gene.
NOS1; nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; N-NOS; NC-NOS; NOS type I; neuronal NOS; constitutive NOS; neuronal nitric oxide synthase; peptidyl-cysteine S-nitrosylase NOS1; NO; bNOS; nNOS; NOS-I; Nos-1; 2310005C01Rik; nitric oxide synthase 1 (neuronal); nos