Official Full Name
NLR family, pyrin domain containing 14
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5.
NLRP14; NLR family, pyrin domain containing 14; NACHT, leucine rich repeat and PYD containing 14 , NALP14; NACHT, LRR and PYD domains-containing protein 14; CLR11.2; GC LRR; Nalp iota; NOD5; nucleotide binding oligomerization domain; leucine rich repeat a