Official Full Name
NLR family, pyrin domain containing 12
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.
NLRP12; NLR family, pyrin domain containing 12; NACHT, leucine rich repeat and PYD containing 12 , NALP12; NACHT, LRR and PYD domains-containing protein 12; CLR19.3; Monarch1; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain; leucine rich repeat and pyrin domain containing 12; PAN6; PYPAF7; RNO2; monarch 1; monarch-1; regulated by nitric oxide; PYRIN-containing APAF1-like protein 7; NACHT, LRR and PYD containing protein 12; NACHT, leucine rich repeat and PYD containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; RNO; FCAS2; NALP12