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nhej1

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Official Full Name
nonhomologous end-joining factor 1
Background
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]
Synonyms
NHEJ1; nonhomologous end-joining factor 1; XLF; non-homologous end-joining factor 1; XRCC4-like factor; protein cernunnos; zgc:85657

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