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nfyb

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Official Full Name
nuclear transcription factor Y, beta
Background
Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene. The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.
Synonyms
NFYB; nuclear transcription factor Y, beta; HAP3; CBF-A; CBF-B; NF-YB; nuclear transcription factor Y subunit beta; Transcription; factor NF-Y, B subunit; CAAT box DNA-binding protein subunit B; nuclear transcription factor Y subunit B; CCAAT-binding transcription factor subunit A; CBF A; NF YB; Transcription factor NF-Y, B subunit; CAAT-box DNA-binding protein subunit B; CAAT-box DNA binding protein subunit

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