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nfkbiz

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Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Background
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion;of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family;of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B;proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I;kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been;found for this gene.
Synonyms
NFKBIZ; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; NF-kappa-B inhibitor zeta; FLJ34463; MAIL; ikB-zeta; ikappaBzeta; IkappaB-zeta; I-kappa-B-zeta; Ikappa B-zeta variant 3; IL-1 inducible nuclear ankyrin-repeat prot