Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.
NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon; NF-kappa-B inhibitor epsilon; IKBE; ikB-E; ikB-epsilon; NF-kappa-BIE; ikappaBepsilon; I-kappa-B-epsilon; zgc:158276