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nfatc4

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Official Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Background
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Synonyms
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; NFAT3; NF-AT3; NF-ATC4; nuclear factor of activated T-cells, cytoplasmic 4; T-cell transcription factor NFAT3

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