This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.
NEK3; NIMA (never in mitosis gene a)-related kinase 3; serine/threonine-protein kinase Nek3; glycogen synthase A kinase; HSPK36; hydroxyalkyl protein kinase; MGC29949; phosphorylase B kinase kinase; serine/threonine protein kinase NEK3; HSPK 36; hydroxyal; hydroxyalkyl-protein kinase; nimA-related protein kinase 3; never in mitosis A-related kinase 3; HSPK36, MGC29949, NEK3