The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
NECAB3; N-terminal EF-hand calcium binding protein 3; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein , APBA2BP, SYTIP2; N-terminal EF-hand calcium-binding protein 3; dJ63M2.4; dJ63M2.5; EF hand calcium binding protein 3; EFCBP3; NIP1; XB51; SYTIP2; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein; Amyloid beta A4 protein binding family A member 2 binding protein; Amyloid beta A4 protein-binding family A member 2-binding protein; APBA2BP; N terminal EF hand calcium binding protein 3; NECA3_HUMAN; Nek2 interacting protein 1; Nek2-interacting protein 1; Neuronal calcium binding protein 3; Neuronal calcium-binding protein 3; STIP3; Synaptotagmin interacting protein 2; X11L binding protein 51; X11L-binding protein 51; EF-hand calcium binding protein 3; neuronal calcium-binding protein NECAB3; synaptotagmin interacting protein STIP3; amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein