The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.
NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (17kD, B17); NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; B17; CI; complex I; mitochondrial respiratory chain; B17 subunit; NADH ubiquinone oxidoreductase B17 subunit; NADH ubiquinone oxidoreductase beta subunit; 6; CI B17; CI-B17; Complex I mitochondrial respiratory chain B17 subunit; Complex I-B17; Complex IB17; MGC13675; MS108; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6; NADH ubiquinone oxidoreductase beta subunit 6; NADH-ubiquinone oxidoreductase B17 subunit; NDUB6_HUMAN; OTTHUMP00000021179; OTTHUMP00000021180; NADH-ubiquinone oxidoreductase beta subunit, 6; complex I, mitochondrial respiratory chain, B1; complex I, mitochondrial respiratory chain, B17 subunit; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6; zgc:73375