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ndufa1

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Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
Background
The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.
Synonyms
NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; CI MWFE; complex I MWFE subunit; MWFE; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex; 1 (7.5kD; MWFE); NADH:ubiquinone oxidoreductase (complex 1); type I dehydrogenase; Complex I MWFE; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 7.5kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1; NADH ubiquinone oxidoreductase (complex 1); NADH ubiquinone oxidoreductase MWFE subunit; NDUFA 1; ZNF 183; ZNF183; complex I-MWFE; OTTHUMP00000023930; NADH oxidoreductase subunit MWFE; NADH-ubiquinone oxidoreductase MWFE subu; CI-MWFE; NADH-ubiquinone oxidoreductase MWFE subunit; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1; zgc:86674

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