The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5 untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
NCR3; natural cytotoxicity triggering receptor 3; LY117, lymphocyte antigen 117; 1C7; CD337; NKp30; Natural killer cell p30 related protein; CD337 antigen; LY117; Lymphocyte antigen 117; NK-p30; OTTHUMP00000029162; OTTHUMP00000029163; OTTHUMP00000029164; OTTHUMP00000029165; activating NK-A1 receptor; activating natural killer receptor p30; natural killer cell p30-related protein; MALS; 1C7, MALS, CD337, LY117, NKp30, NCR3