N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants.
TE2; ARD1; ARD1A; DXS707; MGC71248; N-alpha-acetyltransferase 10, NatA catalytic subunit; OTTHUMP00000026001; OTTHUMP00000026002; OTTHUMP00000064808; OTTHUMP00000064809; OTTHUMP00000180622; OTTHUMP00000180623; ARD1 homolog, N-acetyltransferase; ARD1 homolog A, N-acetyltransferase; N-acetyltransferase ARD1, human homolog of; N-terminal acetyltransferase complex ARD1 subunit homolog A; NAA10; NATD; N(alpha)-acetyltransferase 10, NatA catalytic subunit; N-alpha-acetyltransferase 10; EC 18.104.22.168; TE2, ARD1, NATD, ARD1A, DXS707; zgc:63981; hm:zeh0223; wu:fc66b08