The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical.
MYOM2; myomesin (M-protein) 2, 165kDa; myomesin (M protein) 2 (165kD); myomesin-2; M-protein; M-band protein; myomesin family member 2; 165 kDa titin-associated protein; titin-associated protein, 165 kD; 165 kDa connectin-associated protein; TTNAP; myomesin 2; M-protein, striated muscle