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myh11

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Official Full Name
myosin, heavy chain 11, smooth muscle
Background
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product;is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light;chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through;the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this;gene, and its 3 end overlaps with that of the latter. The pericentric inversion of chromosome 16 (inv(16)(p13q22));produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of;core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This;chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing;generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation.;Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms
MYH11; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 11, smooth muscle; myosin-11; SMHC; SMMHC; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; AAT4; FAA4; FLJ35232; MGC32963; MGC126726; DKFZp686D10126; DKFZp686D19237; myosin; MHC; smooth muscle; heavy polypeptide 11; gizzard smooth muscle; myosin heavy chain, gizzard smooth muscle

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