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myd88

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Official Full Name
myeloid differentiation primary response 88
Background
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Synonyms
MYD88; myeloid differentiation primary response 88; MYD88D; myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88); zgc:103541; zMyD88; myeloid differentiation primary response factor 88