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mxd4

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Official Full Name
MAX dimerization protein 4
Background
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
Synonyms
MXD4; MAX dimerization protein 4; bHLHc12; MAD4; MST149; MSTP149; MAD 4; Mad4 homolog; Max associated protein 4; Max interacting transcriptional repressor MAD4; MST 149; MSTP 149; MXD 4; max dimerizer 4; OTTHUMP00000115253; max-associated protein 4; class C basic helix-loop-helix protein 12; max-interacting transcriptional repressor MAD4