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mvp

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Official Full Name
major vault protein
Background
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
Synonyms
MVP; major vault protein; LRP; lung resistance related protein; VAULT1; lung resistance-related protein; LRP, VAULT1; cb771; wu:fb52b05; wu:fc02g01

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