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mum1

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Official Full Name
melanoma associated antigen (mutated) 1
Background
The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the lg heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenensis of B-cell lymphomas. It is an excellent marker for Hodgkin's and Reed-Sternberg cells of classic Hodgkin's disease in combination with CD30.
Synonyms
MUM1; melanoma associated antigen (mutated) 1; PWWP domain-containing protein MUM1; MUM 1; protein expandere; melanoma ubiquitous mutated protein; mutated melanoma-associated antigen 1; MUM-1; EXPAND1; HSPC211; FLJ14868; FLJ22283; MGC131891; MGC163315; IRF4; interferon regulatory factor 4