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mthfs

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Official Full Name
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Background
The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms
MTHFS; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase; HsT19268; 10-methenyl-tetrahydrofolate synthetase; 5; 5 formyltetrahydrofolate cyclo ligase; 5,10 methenyl tetrahydrofolate synthetase; FLJ30410; Methenyl THF synthetase; Methenyl-THF synthetase; MTHFS_HUMAN; OTTHUMP00000185568