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msx2

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Official Full Name
msh homeobox 2
Background
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
Synonyms
MSX2; msh homeobox 2; FPP; MSH; PFM; CRS2; HOX8; PFM1; homeobox protein MSX-2; msh homeo box 2; homeobox protein Hox-8; msh homeobox homolog 2; msh (Drosophila) homeo box homolog 2 , msh homeobox homolog 2 (Drosophila) , parietal foramina 1 , PFM1; craniosynostosis; type 2; HOX-8; Msx-2; CHOX-8; GHox-8; msh homeo box homolog 2; homeobox-containing Hox-8