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msh3

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Official Full Name
mutS homolog 3
Background
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Synonyms
MSH3; mutS homolog 3; DUP; MRP1; DNA mismatch repair protein Msh3; hMSH3; mismatch repair protein 1; divergent upstream protein; mutS homolog 3 (E. coli); mutS (E. coli) homolog 3; MGC163306; MGC163308; si:dkey-56d12.1