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msh2

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Official Full Name
mutS homolog 2
Background
The MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma,While germline MSH2 mutations are responsible for approximately 50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids.
Synonyms
MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); COCA1, mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1); DNA mismatch repair protein Msh2; HNPCC; HNPCC1; hMSH2; FCC1; COCA1; LCFS2; COCA1, FCC1, HNPCC, HNPCC1, LCFS2, MSH2; mutS homolog 2 (E. coli); zgc:55333; wu:fc06b02; wu:fc13e09; mismatch repair protein Msh2