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mrvi1

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Official Full Name
murine retrovirus integration site 1 homolog
Background
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Synonyms
MRVI1; murine retrovirus integration site 1 homolog; protein MRVI1; inositol 1; 4; 5 triphosphate associated cGMP kinase substrate; IP3R associated cGMP kinase substrate; IRAG; JAW1L; JAW1-related protein MRVI1; IP3R-associated cGMP kinase substrate; inos; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; IRAG, JAW1L