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mmp11

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Official Full Name
matrix metallopeptidase 11 (stromelysin 3)
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Synonyms
MMP11; matrix metallopeptidase 11 (stromelysin 3); ST3; SL-3; STMY3; stromelysin-3; MMP-11; stromelysin III; SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; matrix metalloproteinase 11 (stromelysin 3); SWI/SNF related, matrix associated, actin dependent reg