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mllt11

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Official Full Name
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
Background
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
Synonyms
MLLT11; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11; protein AF1q; AF1Q; ALL1 fused gene from chromosome 1q; MLLT 11; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila) translocated to 11; RP11 316M1.10; OTTHUMP00000033120; ALL1-fused gene from chromosome 1q; RP11-316M1.10; fc23g02; wu:fc23g02; si:ch211-210h11.4