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mll4

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Official Full Name
myeloid/lymphoid or mixed-lineage leukemia 4
Background
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.
Synonyms
MLL4; myeloid/lymphoid or mixed-lineage leukemia 4; histone-lysine N-methyltransferase MLL4; KMT2D; WBP-7; trithorax homolog 2; trithorax homologue 2; WW domain binding protein 7; WW domain-binding protein 7; lysine N-methyltransferase 2D; mixed lineage l

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