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mif

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Official Full Name
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Background
MIF is a proinflammatory cytokine involved in many inflammatory reactions and disorders. MIF (macrophage migration inhibitory factor) was one of the first cytokines to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity. MIF is involved in both autoimmune disorders and tumorigenesis.
Synonyms
MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor); GIF; GLIF; MMIF; Macrophage migration inhibitory factor; EC=5.3.2.1; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; EC=5.3.3.12; Phenylpyruvate tautomerase; OTTHUMP00000198465