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med24

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Official Full Name
mediator complex subunit 24
Background
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Synonyms
MED24; mediator complex subunit 24; cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa , CRSP4, THRAP4, thyroid hormone receptor associated protein 4; mediator of RNA polymerase II transcription subunit 24; CRSP100; DRIP100; KIAA0130; TRAP100; CRSP complex subunit 4; thyroid hormone receptor associated protein 4; thyroid hormone receptor-associated protein 4; activator-recruited cofactor 100 kDa component; cofactor required for Sp1 transcriptional activation subunit 4; mediator of RNA polymerase II transcription, subunit 24 homolog; vitamin D3 receptor-interacting protein complex 100 kDa component; vitamin D3 receptor-interacting protein complex component DRIP100; thyroid hormone receptor-associated protein complex 100 kDa component; cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa; CRSP4; ARC100; THRAP4; MGC8748; fc05c04; wu:fc05c04; lsn; lessen; protein lessen; trap100 homolog; 100 kDa thyroid