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mdm4

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Official Full Name
MDM4, p53 regulator
Background
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latters degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Synonyms
MDM4; MDM4, p53 regulator; HDMX; MDMX; MRP1; protein Mdm4; protein Mdmx; MDM4 protein variant G; MDM4 protein variant Y; MDM4-related protein 1; mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog; double minute 4, human homolog of; p53-binding protein; Mdm4 p53 binding protein homolog (mouse); Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) , mouse double minute 4, human homolog of; p53 binding protein; Mdm4, transformed 3T3 cell double minute 4, p53 binding protein; MGC132766; DKFZp781B1423; HDMX, MDMX, MRP1; wu:fa09h09; wu:fi33d10; double minute 4 protein; p53-binding protein Mdm4; transformed 3T3 cell double minute 4 homolog; Mdm4, transformed 3T3 cell double minute 4, p53