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mdk

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Official Full Name
midkine (neurite growth-promoting factor 2)
Background
This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Synonyms
MDK; midkine; MK; Mek; retinoic acid-responsive protein; retinoic acid-induced differentiation factor; midkine (neurite growth-promoting factor 2); NEGF2; FLJ27379; ARAP; amphiregulin-associated protein; midgestation and kidney protein; neurite outgrowth-promoting protein; neurite outgrowth-promoting factor 2; RIHB; RI-HB; retinoic acid-induced heparin-binding protein

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