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mdc1

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Official Full Name
mediator of DNA-damage checkpoint 1
Background
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Synonyms
MDC1; mediator of DNA-damage checkpoint 1; NFBD1; mediator of DNA damage checkpoint protein 1; nuclear factor with BRCT domains 1; mediator of DNA damage checkpoint 1; homologue to Drosophila photoreceptor protein calphotin

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