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mcm8

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Official Full Name
minichromosome maintenance complex component 8
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are;essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM;proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of;replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central;domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and;7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively;spliced transcript variants encoding distinct isoforms have been described.
Synonyms
MCM8; minichromosome maintenance complex component 8; C20orf154, chromosome 20 open reading frame 154; DNA replication licensing factor MCM8; dJ967N21.5; MGC4816; MGC12866; MGC119522; MGC119523; REC; REC homolog (Drosophila); REC homolog; minichromosome; minichromosome maintenance 8; MCM8 minichromosome maintenance deficient 8; C20orf154; REC, C20orf154, dJ967N21.5; DNA helicase MCM8