MCL-1 (Myeloid cell leukemia-1) is a member of the BCL-2 family. The carboxy terminal of MCL-1 and BCL-2 share significant sequence homology. Expression of MCL-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in BCL-2. Like BCL-2, MCL-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis.
MCL1; myeloid cell leukemia sequence 1 (BCL2-related); induced myeloid leukemia cell differentiation protein Mcl-1; BCL2L3; Mcl 1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1; TM; EAT; MCL1L; MCL1S; Mcl-1; MCL1-ES; bcl2-L-3; mcl1/EAT; MGC1839; MGC104264; myeloid cell leukemia protein MCL-1