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MAZ (MYC associated zinc finger protein) is a protein encoded by the MAZ gene in humans. MAZ gene is located in the 1-band and 2-subband (16.P11.2) of the long arm region of human autosomal 16. The MAZ gene transcript is 2.7 kb mRNA, encoding 477 amino acids and a MAZ protein with a molecular weight of approximately 60 kDa is obtained. MAZ protein plays a key role in the transcriptional initiation of certain target genes such as c-Myc and RAG-2. At the same time, MAZ protein also plays a role in the termination of transcription of some genes such as endothelial nitric oxide synthase (eNOS), Sp4, and telomerase. Therefore, MAZ is a transcription factor that has dual regulatory roles in initiating transcription of certain genes and terminating transcription of target genes.
MAZ Gene and Cancer
In recent years, studies have found that the expression of MAZ in many human malignant tumors is abnormally high, and is closely related to the occurrence and development of tumors. For example, the abnormal expression of MAZ in malignant glioma is higher than that in normal brain cells and astrocytes, and the expression of MAZ in malignant glioma stem cells is higher than that in malignant glioma, suggesting that MAZ may play the role of proto-oncogene in malignant glioma.
In addition, the expression of MAZ is abnormally elevated in liposarcoma, and it can cooperate with SPIN1, a histone-encoded reading gene, to co-enhance the expression of GDNF (glial cell-derived nutrient factor) in RET signaling pathway, thereby promoting the proliferation or reducing the apoptosis of liposarcoma cells. When the MAZ or SPIN1 gene is knocked down, the expression levels of GDNF and the activated RET protein are lowered, and the proliferation and survival of liposarcoma cells are also down-regulated.
It is well known that c-Myc gene is one of the important members of MYC gene family. The c-Myc gene is one of the most intensive proto-oncogenes and is closely related to hepatocarcinogenesis. Some scholars have found that P19 cells derived from neural ectoderm must have MAZ to activate the ME1a1-mediated expression of c-Myc gene. MAZ also plays a role in the distant metastasis of hepatocellular garcinoma (HCC) and the tumor-free survival time of postoperative patients.
MAZ can promote the expression of MCF-7 cells and enhance the invasion and metastasis ability of breast cancer cells. In addition, MAZ can bind to the pA1 sequence, thus specifically promoting the expression of PPAR-1 in breast cancer epithelial cells. In normal mammary epithelium, when the expression of MAZ gene is up-regulated, PPAR-1 expression can also be up-regulated, which promotes the occurrence of breast cancer.
1. Liu Wei, et al. Expression and significance of MAZ gene in hepatocellular carcinoma [J]. Journal of Clinical and Experimental Pathology, 2016, (6).
2. Liu Wei. The role and function of MAZ gene in hepatocellular carcinoma [D]. Guilin Medical College, 2016.