The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
MATK; megakaryocyte-associated tyrosine kinase; megakaryocyte-associated tyrosine-protein kinase; CHK; Csk homologous kinase; Csk type protein tyrosine kinase; CTK; DKFZp434N1212; hematopoietic consensus tyrosine lacking kinase; HHYLTK; hydroxyaryl protein kinase; HYL; HYL tyrosine kinase; HYLTK; leukocyte carboxyl terminal src kinase relat; EC 220.127.116.11; Leukocyte carboxyl terminal src kinase related; Lsk; Megakaryocyte associated tyrosine kinase; Megakaryocyte associated tyrosine protein kinase; MGC1708; MGC2101; Protein kinase HYL; Tyrosine kinase MATK; Tyrosine protein kinase CTK; Tyrosylprotein kinase; Csk-homologous kinase; hydroxyaryl-protein kinase; tyrosine-protein kinase CTK; Csk-type protein tyrosine kinase; leukocyte carb