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masp1

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Official Full Name
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Background
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
Synonyms
MASP1; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); CRARF, mannan binding lectin serine protease 1 (C4/C2 activating component of Ra reactive factor) , PRSS5; mannan-binding lectin serine protease 1; MASP; Complement factor MASP-3; Complement factor MASP3; Complement-activating component of Ra-reactive factor; CRARF; Mannose binding lectin associated serine protease 1; Mannose binding protein associated serine protease; Mannose-binding lectin-associated serine protease 1; Mannose-binding lectin-associated serine protease-1; PRSS 5; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; OTTHUMP00000209926; OTTHUMP00000209927; OTTHUMP00000209928; OTTHUMP00000209929; OTTHUMP00000209930; mannose-binding protein-associated se; MAP1; MASP3; MAp44; PRSS5; CRARF1; 3MC1; mannan-binding lectin associated serine protease 3; mannan-binding lectin serine protease 1 (C4/C2 activating comp; MASP-1/3

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