Macrophage receptor MARCO is a protein that in humans is encoded by the MARCO gene. The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an intracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
MARCO; SCARA2; Macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO_HUMAN; Scavenger receptor class A member 2; scavenger receptor class A; member 2; scavenger receptor class A, member 2; putative scavenger receptor MARCO