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map3k12

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Official Full Name
mitogen-activated protein kinase kinase kinase 12
Background
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
Synonyms
MAP3K12; mitogen-activated protein kinase kinase kinase 12; ZPK; DLK; dual leucine zipper kinase DLK; MEKK12; MUK; ZPKP1; protein kinase MUK; MAPK-upstream kinase; mixed lineage kinase; leucine zipper protein kinase; dual leucine zipper bearing kinase; zgc:77370

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