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map2k5

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Official Full Name
mitogen-activated protein kinase kinase 5
Background
Mitogen-activated protein kinase kinase 5 (MKK5) belongs to the serine/threonine protein kinase family and the MAPK subfamily (MAP2K, MKK or MEKs). MKK5 specifically phosphorylates erk5/MAPK7 within the kinase activation loop pThr-E-pTyr motif. After activation erk5 phosphorylates MKK5 on multiple phosphoserine residues. The MKK5/erk5 pathway may play an important role in prostate and breast cancer.
Synonyms
MAP2K5; mitogen-activated protein kinase kinase 5; PRKMK5; dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAPKK5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; fb73f02; wu:fb73f02; zgc:172137