Official Full Name
microtubule-actin crosslinking factor 1
The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family;forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one;of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule;binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may;function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the;microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have;been described.
MACF1; microtubule-actin crosslinking factor 1; microtubule-actin cross-linking factor 1; ABP620; Acf7; Aclp7; Actin cross linking family 7; MACF; Microtubule actin crosslinking factor 1; mKIAA0465; R74989; rabeculin alpha; trabeculin alpha; actin cross-linking family 7; actin-crosslinking protein 7