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macc1

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Official Full Name
metastasis associated in colon cancer 1
Background
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860);pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility,;invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic;indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 (PubMed 19098908)).
Synonyms
MACC1; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; 7A5; SH3BP4L; putative binding protein 7a5; SH3 domain-containing protein 7a5