This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
M6PR; mannose-6-phosphate receptor (cation dependent); cation-dependent mannose-6-phosphate receptor; 46 kDa mannose 6 phosphate receptor; Cation dependent mannose 6 phosphate receptor; Cation dependent mannose 6 phosphate receptor precursor; Cation independent mannose 6 phosphate receptor; CD Man 6 P receptor; CD MPR; CD222; CIMPR; FLJ32994; IGFR2; Insulin like growth factor 2 receptor; M6PR protein; Man6PR; Mannose 6 phosphate receptor; MPR 46; MPR46; MPRD; MPRI; SMPR; Mr 46,000 Man6PR; CD Man-6-P receptor; small mannose 6-phosphate receptor; 46-kDa mannose 6-phosphate receptor; CD-MPR; MPR-46; CD-MPR, FLJ32994, MPR 46, MPR-46, MPR46, SMPR, M6PR; zgc:77757; wu:fj81h11