The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; CD 18; CD18; CD18 antigen; LT beta R; LTBETAR; Lymphotoxin B receptor; Lymphotoxin beta receptor; TNFR superfamily member 3; TNFR2RP; TNFRII; TNFRRP; TNFRSF 3; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2 related protein; Tumor necrosis factor receptor superfamily member 3 precursor; TNF-RIII; TNFR-III; OTTHUMP00000238625; OTTHUMP00000238626; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor receptor type II; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily, member 3; CD18, TNFCR, D12S370, TNFR-RP, TNFRSF3, TNFR2-RP, LT-BETA-R, TNF-R-III