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Official Full Name
lymphotoxin beta (TNF superfamily, member 3)
Background
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
LTB; lymphotoxin beta (TNF superfamily, member 3); TNFC; lymphotoxin-beta; p33; TNFSF3; LT beta; lymphotoxin beta; tumor necrosis factor C; TNF-C; LT-beta; OTTHUMP00000029185; OTTHUMP00000215145; tumor necrosis factor ligand superfamily member 3

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