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lsm1

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Official Full Name
LSM1, U6 small nuclear RNA associated
Background
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
Synonyms
LSM1; LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); U6 snRNA-associated Sm-like protein LSm1; anti-LSM1; Cancer associated Sm like protein; Cancer associated Sm-like; Cancer-associated Sm-like; CASM; Lsm1 protein; LSM1_HUMAN; Small nuclear ribonuclear CaSm; U6 snRNA associated Sm-like protein LSm1; YJL124C; cancer-associated Sm-like protein; CASM, YJL124C, LSM1; LSM1, U6 small nuclear RNA associated; zgc:101136; LSM1 homolog, U6 small nuclear RNA associated