LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer,
and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein
uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations
in LPL are linked to many disorders of lipoprotein metabolism.